論文

2024年

原著論文(英文)*責任著者 
1.  Mayo Higashihara, Hirofumi Enomoto, Tomoko Sumi, Tatsuya Moriyama, Nobuhiro Zaima*. Similar distribution between EPA-containing phosphatidylcholine and mesenchymal stem cell in the aortic wall of abdominal aortic aneurysm model rat which fed low-EPA content diet.  Journal of Oleo Science (In Press) 2024

2.  Shohei Sakuda*, Masaki Sunaoka, Maho Terada, Ayaka Sakoda, Natsumi Ishijima, Noriko Hakoshima, Kenichi Uchida, Hirofumi Enomoto, Tomohiro Furukawa. Inhibition of Aflatoxin Production in Aspergillus flavus by a Klebsiella sp. and Its Metabolite Cyclo(l-Ala-Gly). Toxins (In Press) 2024

3.   Naoko Goto-Inoue*, Shudai Sasaki, Tsukasa Mori, Hirofumi Enomoto, Sakiko Nakamura, Hideo Yokota, Hiroshi Yamashita.  Assessing molecular localization of symbiont microalgae in coral branches through mass spectrometry imaging. Marine Biotechnology (In press), 2024



2023年

原著論文(英文)*責任著者
1.  Abdelrahman Elamin, Hirofumi Enomoto, Maiko Watanabe, Shohei Sakuda*.  The mechanism of ochratoxin contamination of licorice root. Toxins, 15(3), 219, 2023年3月

2.  Tomohiro Furukawa*, Masayo Kushiro, Hiroyuki Nakagawa, Hirofumi Enomoto, Shohei Sakuda. Low-dose ethanol increases aflatoxin production due to the adh1-dependent incorporation of ethanol into aflatoxin biosynthesis. iScience, 26(2), 106051, 2023年2月

3.  Hirofumi Enomoto*, Nobuhiro Zaima. Desorption electrospray ionization-mass spectrometry imaging of carnitine and imidazole dipeptides in pork chop tissues. Journal of Chromatography B, 1216, 123601, 2023年1月


2022年

原著論文(英文) *責任著者

1.  Hirona Kugo, Hirofumi Enomoto, Kenichi Yanagimoto, Hiroki Tanaka, Tatsuya Moriyama, Nobuhiro Zaima*.  Eicosapentaenoic acid is associated with the attenuation of dysfunctions of mesenchymal stem cells in the abdominal aortic aneurysm wall.  Food & Function, 13(14), 7540-7547. 2022年6月.

2.  Enomoto Hirofumi*. Distribution analysis of jasmonic acid-related compounds in developing Glycine max L. (soybean) seeds using mass spectrometry imaging and liquid chromatography-mass spectrometry. Phytochemical Analysis , 33(2), 194-203 2022年3月 

 
3.  Samuel Tam, Kenichi Uchida, Hirofumi Enomoto, Senji Takahashi, Koichi Makimura, Shohei Sakuda*.  A new metabolite, mannogeranylnerol, specifically produced at body temperature by Schizophyllum commune, a causative fungus of human mycosis.  The Journal of Antibiotics, 75, 243-246, 2022年1月.

解説(和文)  *責任著者
1. 榎元廣文*. 食肉科学分野への質量分析イメージングの応用. 食肉の科学, 63 (1), 17-22, 2022.

2021年

原著論文(英文) *責任著者 

1. Hirofumi Enomoto*.  Unique distribution of ellagitannins in ripe strawberry fruit revealed by mass spectrometry imaging.  Current Research in Food Science, 4, 821-828, 2021.

2. Hirofumi Enomoto*, Koji Miyamoto. Unique localization of jasmonic acid-related compounds in developing Phaseolus vulgaris L. (common bean) seeds revealed through desorption electrospray ionization-mass spectrometry imaging. Phytochemistry 188 112812 2021年8月

3. Hirofumi Enomoto*, Shiro Takeda. Mass spectrometry imaging of diacyl-, alkylacyl-, and plasmalogen-phosphatidylethanolamines in pork chop tissues. Journal of Food Measurement and Characterization 15 5047-4059 2021年7月23日

4. Takeda Shiro*, Uchiyama Jumpei, Sugita Kazutoshi, Enomoto Hirofumi, Ahhmed Abdulatef M, Kinoshita Yuki, Mizunoya Wataru, Arima Yoshitaka, Sakata Ryoichi. Functionality of liquid smoke as an antimicrobial in cooked meat products: Liquid smoke suppresses spoilage-related lactic acid bacteria. Food Science and Technology Research 27(5) 759-768 2021年7月

5. Hirofumi Enomoto*, Shiro Takeda, Hajime Hatta. Spatial analysis of phosphatidylinositol molecular species in pork chop tissues using matrix-assisted laser desorption/ionization-mass spectrometry imaging. Journal of Oleo Science 70(7) 979-987 2021年7月

6. Enomoto Hirofumi*. Adhesive film applications help to prepare strawberry fruit sections for desorption electrospray ionization-mass spectrometry imaging. Bioscience, Biotechnology, and Biochemistry 85(6) 1341-1347 2021年5月25日

7. Rena Fujishima, Hirona Kugo, Kenichi Yanagimoto, Hirofumi Enomoto, Tatsuya Moriyama, Nobuhiro Zaima*. Similar distribution of orally administered eicosapentaenoic acid and M2 macrophage marker in the hypoperfusion-induced abdominal aortic aneurysm wall. Food & Function 12(8) 3469-3475 2021年4月

8. Emi Yumoto, Masaki Sato, Tomoyoshi Kubota, Hirofumi Enomoto, Koji Miyamoto, Hisakazu Yamane, Jinichiro Koga*. Direct LC-ESI–MS/MS analysis of plant glucosylceramide and ceramide species with 8E and 8Z isomers of the long chain base. Bioscience, Biotechnology, and Biochemistry 85(2) 205-210 2021年2月18日 

その他
1. 古川智宏, 榎元廣文, 井上博喜.   赤かび病被害小麦穀粒におけるかび毒蓄積の空間的解析 .  年報 / 飯島藤十郎記念食品科学振興財団 編 = Annual report / The Tojuro Iijima Foundation for Food Science and Technology 37 356-361, 2021.

2020年

原著論文(英文)  *責任著者 

1. Enomoto Hirofumi*. Mass Spectrometry Imaging of Flavonols and Ellagic Acid Glycosides in Ripe Strawberry Fruit. Molecules 25(20) 4600 2020年10月9日

2. Yoshihito Shinozaki, Bertr, P. Beauvoit, Masaru Takahara, Shuhei Hao, Kentaro Ezura, Marie Helene Andrieu, Keiji Nishida, Kazuki Mori, Yutaka Suzuki, Satoru Kuhara, Hirofumi Enomoto, Miyako Kusano, Atsushi Fukushima, Tetsuya Mori, Mikiko Kojima, Makoto Kobayashi, Hitoshi Sakakibara, Kazuki Saito, Yuya Ohtani, Camille Bénard, Duyen Prodhomme, Yves Gibon, Hiroshi Ezura, Tohru Ariizumi*. Fruit setting rewires central metabolism via gibberellin cascades. Proceedings of the National Academy of Sciences of the United States of America 117(38) 23970-23981 2020年9月22日

3. Shiro Takeda*, Sakurako Kaneko, Kazuyuki Sogawa, Abdulatef M Ahhmed, Hirofumi Enomoto, Shinpei Kawarai, Kensuke Taira, Wataru Mizunoya, Masato Minami, Ryoichi Sakata. Isolation, Evaluation, and Identification of Angiotensin I-Converting Enzyme Inhibitory Peptides from Game Meat. Foods 9(9) 1168 2020年8月25日

4. Shiro Takeda*, Akiko Harauma, Mariko Okamoto, Hirofumi Enomoto, Toshiji Kudo, Takehito Suzuki, Wataru Mizunoya, Toru Moriguchi*. Effects of whey protein hydrolysate on growth promotion and immunomodulation in mouse pups in artificial rearing system. Animal Science Journal 91(1) e13395 2020年6月2日

5. Hirofumi Enomoto*, Takashi Nirasawa. Localization of Flavan-3-ol Species in Peanut Testa by Mass Spectrometry Imaging. Molecules 25(10) 2373 2020年5月

6. Hirofumi Enomoto *, Masahiro Kotani, Takayuki Ohmura. Novel Blotting Method for Mass Spectrometry Imaging of Metabolites in Strawberry Fruit by Desorption/Ionization using Through Hole Alumina Membrane. Foods 9(4) 408 2020年4月1日

7. Hirofumi Enomoto*, Tomohiro Furukawa Shiro Takeda, Hajime Hatta, Nobuhiro Zaima. Unique distribution of diacyl-, alkylacyl-, and alkenylacyl-phosphatidylcholine species visualized in pork chop tissues by matrix-assisted laser desorption/ionization–mass spectrometry imaging. Foods 9(2) 205 2020年2月16日

総説(和文)  *責任著者 

1. 榎元廣文*. 質量分析イメージング法を用いたインゲンマメ未熟種子中のアブシシン酸および12-オキソ-フィトジエン酸の可視化. 植物の生長調節 55(2) 77-83 2020年12月 

2. 榎元 廣文*. 農畜産物中の代謝物の分布解析への質量分析イメージングの応用. JMS Mycotoxins 70(2) 75-82 2020年3月 

2019年

原著論文(英文)  *責任著者 

1. Hirofumi Enomoto*, Senji Takahashi, Shiro Takeda and Hajime Hatta. Distribution of flavan-3-ol species in ripe strawberry fruit revealed by matrix-assisted laser desorption/ionization-mass spectrometry imaging. Molecules 25(1) 103 2019年12月26日.

2. Hirofumi Enomoto*, Shiro Takeda, Hajime Hatta, Nobuhiro Zaima. Tissue-specific distribution of sphingomyelin species in pork chop revealed by matrix-assisted laser desorption/ionization–imaging mass spectrometry. Journal of Food Science 84(7) 1758-1763 2019年7月17日

2018年

原著論文(英文)  *責任著者 

1. Chien-Hsiang Ni, Chih-Shang Lee, Fu-Yuan Chuan, Hirofumi Enomoto, Shiro Takeda*, Liang-Chuan Lin*, Ryoichi Sakata. Investigation of the chemical composition and functional proteins of chicken gizzard inner lining. Food Science and Technology Research 24(5) 893-901 2018年10月

2. Yu Wang, Hirofumi Enomoto, Jufang Shen, Hajime Hatta*. Effect of Egg White Hydrolysates on the Shrinkage, Cooking Loss and Texture of Pork Meat Slices. Advance Journal of Food Science and Technology 14(6) 186-193 2018年10月

3. Hirofumi Enomoto*, Takuya Sensu, Emi Yumoto, Takao Yokota, and Hisakazu Yamane. Derivatization for detection of abscisic acid and 12-oxo-phytodienoic acid using matrix-assisted laser desorption/ionization-imaging mass spectrometry. Rapid Communications in Mass Spectrometry 32(17) 1565-1572 2018年9月15日

4. Hirofumi Enomoto*, Kei Sato, Koji Miyamoto, Akira Ohtsuka, Hisakazu Yamane. Distribution analysis of anthocyanins, sugars, and organic acids in strawberry fruits using matrix-assisted laser desorption/ionization-imaging mass spectrometry. Journal of Agricultural and Food Chemistry 66(19) 4958-4965 2018年5月16日

5. Yu-Tse Liu, Fu-Yuan Cheng, Shiro Takeda, Hirofumi Enomoto, Gow-Chin Yen, Liang-Chuan Lin*, Ryoichi Sakata. Production, Analysis and in Vivo Antihypertensive Evaluation of Novel Angiotensin-I-converting Enzyme Inhibitory Peptides from Porcine Brain. Food Science and Technology Research 24(3) 541-550 2018年2月

2017年

原著論文(英文)  *責任著者 

1. Hirofumi Enomoto*, Takuya Sensu, Kei Sato, Futoshi Sato, Thanai Paxton, Emi Yumoto, Koji Miyamoto, Masashi Asahina, Takao Yokota, Hisakazu Yamane. Visualisation of abscisic acid and 12-oxo-phytodienoic acid in immature Phaseolus vulgaris L. seeds using desorption electrospray ionisation-imaging mass spectrometry. Scientific Reports 7 42977 2017年2月17日

2013年

原著論文(英文)  *責任著者 

1. Jinping Zhao, Hui Zhao, Xiaoyan Wang, Rong Huang, Hirofumi Enomoto, Zhikun He, Can-Peng Li*. Characteristics and enhanced antioxidant activity of egg white protein selenized by dry-heating in the presence of selenite. Journal of Agricultural and Food Chemistry 61(12) 3131-3139 2013年3月4日

2012年

原著論文(英文)  *責任著者 

1. Yukihiro Yoshimura, Hirofumi Enomoto, Tatsuya Moriyama, Yukio Kawamura, Mitsutoshi Setou, Nobuhiro Zaima*. Visualization of anthocyanin species in rabbiteye blueberry Vaccinium ashei by matrix-assisted laser desorption/ionization imaging mass spectrometry. Analytical and Bioanalytical Chemistry 403(7) 1885-1895 2012年3月8日

2011年

原著論文(英文)  *責任著者 

1. Nobuhiro Zaima*, Takeshi Sasaki, Hiroki Tanaka, Xian Wu Cheng, Kenji Onoue, Takahiro Hayasaka, Naoko Goto-Inoue, Hirofumi Enomoto, Naoki Unno, Masafumi Kuzuya, Mitsutoshi Setou*. Imaging mass spectrometry-based histopathologic examination of atherosclerotic lesions. Atherosclerosis 217(2) 427-432 2011年4月9日

2. Hirofumi Enomoto, Yuki Sugiura, Mitsutoshi Setou, Nobuhiro Zaima*. Visualization of phosphatidylcholine, lysophosphatidylcholine and sphingomyelin in mouse tongue body by matrix-assisted laser desorption/ionization imaging mass spectrometry. Analytical and Bioanalytical Chemistry 400(7) 1913-1921 2011年4月7日

3. Nobuhiro Zaima*, Naoko Goto-Inoue, Takahiro Hayasaka, Hirofumi Enomoto, Mitsutoshi Setou. Authenticity assessment of beef origin by principal component analysis of matrix-assisted laser desorption/ionization mass spectrometric data. Analytical and Bioanalytical Chemistry 400(7) 1865-1871 2011年3月1日

2010年

原著論文(英文)  *責任著者 

1. Hirofumi Enomoto, Takayuki Ishimaru, Can-Peng Li, Yoko Hayashi, Naotoshi Matsudomi, Takayoshi Aoki*. Phosphorylation of ovalbumin by dry-heating in the presence of pyrophosphate: Effect of carbohydrate chain on the phosphorylation level and heat stability. Food Chemistry 122(3) 526-532 2010年10月

2. Can-Peng Li*, Deyi Chen, Jianlin Peng, Hirofumi Enomoto, Yoko Hayashi, Cong Li, Lingcheng Ou, Takayoshi Aoki. Improvement of functional properties of whey soy protein phosphorylated by dry-heating in the presence of pyrophosphate. LWT-Food Science and Technology 43(6) 919-925 2010年7月

総説(英文)  *責任著者 


1. Can-Peng Li*, Hirofumi Enomoto, Yoko Hayashi, Hui Zhao*, Takayoshi Aoki. Recent advances in phosphorylation of food proteins: A review. LWT-Food Science and Technology 43(9) 1295-1300 2010年11月

2009年

原著論文(英文)  *責任著者 

1. Hirofumi Enomoto, Yoko Hayashi, Can-Peng Li, Shiniti Ohki, Hideo Ohtomo, Masayuki Shiokawa, Takayoshi Aoki*. Glycation and phosphorylation of α-lactalbumin by dry-heating: Effect on protein structure and physiological functions. Journal of Dairy Science 92(7) 3057-3068 2009年7月

2. Can-Peng Li, Yoko Hayashi, Hirofumi Enomoto, Fangyu Hu, Yoriko Sawano, Masaru Tanokura, Takayoshi Aoki*. Phosphorylation of proteins by dry-heating in the presence of pyrophosphate and some characteristics of introduced phosphate groups. Food Chemistry 114(3) 1036-1041 2009年6月

3. Hirofumi Enomoto, Shiho Nagae, Yoko Hayashi, Can-Peng Li, Hisham R. Ibrahim, Yasushi Sugimoto, Takayoshi Aoki*. Improvement of Functional Properties of Egg White Protein through Glycation and Phosphorylation by Dry-heating. Asian-Australasian Journal of Animal Sciences 22(4) 591-597 2009年4月

4. Yoko Hayashi, Saori Nagano, Hirofumi Enomoto, Can-Peng Li, Yasushi Sugimoto, Hisham R. Ibrahim, Hajime Hatta, Chieno Takeda, Takayoshi Aoki*. Improvement of Foaming Property of Egg White Protein by Phosphorylation through Dry-Heating in the Presence of Pyrophosphate. Journal of Food Science 74(1) C68-C72 2009年1月

2008年

原著論文(英文)  *責任著者 

1. Yoko Hayashi, Can-Peng Li, Hirofumi Enomoto, Hisham R. Ibrahim, Yasushi Sugimoto, Takayoshi Aoki*. Improvement of functional properties of ovotransferrin by phosphorylation through dry-heating in the presence of pyrophosphate. Asian-Australasian Journal of Animal Sciences 21(4) 596-602 2008年4月

2. Hirofumi Enomoto, Can-Peng Li, Kentaro Morizane, Hisham R. Ibrahim, Yasushi Sugimoto, Shinichi Ohki, Hideo Ohtomo, Takayoshi Aoki*. Improvement of functional properties of bovine serum albumin through phosphorylation by dry-heating in the presence of pyrophosphate. Journal of Food Science 73(2) C84-C91 2008年3月

2007年

原著論文(英文)  *責任著者 

1. Hirofumi Enomoto, Can-Peng Li, Kentaro Morizane, Hisham R. Ibrahim, Yasushi Sugimoto, Shinichi Ohki, Hideo Ohtomo, Takayoshi Aoki*. Glycation and phosphorylation of β-lactoglobulin by dry-heating: Effect on protein structure and some properties. Journal of Agricultural and Food Chemistry 55(6) 2392-2398 2007年3月

2005年

原著論文(英文)  *責任著者 

1. Can-Peng Li, Hirofumi Enomoto, Shiniti Ohki, Hideo Ohtomo, Takayoshi Aoki*. Improvement of functional properties of whey protein isolate through glycation and phosphorylation by dry heating. Journal of Dairy Science 88(12) 4137-4145 2005年12月

招待講演


2022年

榎元 廣文. (シンポジウム2) 食品の品質理解に向けた質量分析イメージングの展開. 第31回 日本バイオイメージング学会学術集会. 大阪大学 銀杏会館. 2022年9月3日

Enomoto Hirofumi.  (Award Lecture) Spatial Analysis of Phosphatidylinositol Molecular Species in Pork Chop Tissues Using Matrix-assisted Laser Desorption/ionization-Mass Spectrometry Imaging. 2nd World Congress on Oleo Science. Online. 2022年8月26日

2021年

榎元 廣文. 農作物の質量分析イメージング. かび毒委託プロ・推進会議(農研機構). 2021年11月19日

2020年

榎元 廣文. 農畜産物中の栄養機能性成分の質量分析イメージング解析. BRUKER オンデマンドMSフォーラム2020  2020年  

2019年

Hirofumi Enomoto. KEYNOTE LECTURE: Application of Mass Spectrometry Imaging to Lipid Analysis of Meats. 17th Euro Fed Lipid Congress And Expo Seville(Seville, Spain)  2019年10月21日 

Hirofumi Enomoto. (Symposium 8) Mass Spectrometry Imaging of Metabolites in Agricultural Products. The 6th International Symposium on Bioimaging & The 28th Annual Meeting of the Bioimaging Society (Teikyo university, Tokyo)  2019年9月23日 

榎元廣文. (特別講演 S-2) 質量分析イメージングを用いた農産物中の代謝物の可視化. 日本マイコトキシン学会 第84回学術講演会(帝京大学宇都宮キャンパス)  2019年8月23日

榎元廣文. Visualization of abscisic acid and 12-oxo-phytodienoic acid in immature Phaseolus vulgaris L. seeds using imaging mass spectrometry. 理研CSRSセミナー  2019年4月25日

榎元廣文. イチゴ中の栄養・機能性成分のイメージング質量分析法を用いた分布解析. 第103回 日本栄養·食糧学会関東支部大会シンポジウム「イチゴに秘められた機能性と可能性」(宇都宮大学、栃木)  2019年3月16日  
 

2017年

榎元廣文. イメージング質量分析法による脂質の局在解析. 第17回基準油脂分析試験法セミナー  2017年10月20日 

受賞

2023年3月
冲永荘一学術文化奨励賞.榎元廣文.

2022年4月

第25回 J Oleo Sci Editors賞.  日本油化学会.  

「Spatial analysis of phosphatidylinositol molecular species in pork chop tissues using matrix-assisted laser desorption/ionization-mass spectrometry imaging. J Oleo Sci 70 (7), 979-987 (2021)」榎元廣文, 竹田志郎, 八田一 .

2011年3月
日本農芸化学会2011年度大会 トピックス賞.  
「卵黄中の新規構造の発見」榎元廣文, 瀬藤光利, 財満信宏.  


産業財産権

特願2022-63509 ゲラニルネロールグリコシドおよびその幾何異性体.  作田庄平, 槇村浩一, 内田健一, 高橋宣治, 榎元廣文, 譚承堯. 2022.

特願2012-167536 卵白アルブミン分解物を含有する脂質代謝改善剤.  大塚彰, 藤田弘志, 榎元廣文. 2012. 


新聞・メディア報道

2020年

ナショナルジオグラフィック. 質量分析イメージングで食の安全や品質の向上の貢献.  2020年12月. →https://special.nikkeibp.co.jp/atclh/TS/19/teikyo05/

2011年

科学新聞. 卵黄中の新規構造を発見. 2011年3月

その他

アプリケーションノート
Hirofumi Enomoto*. MALDI-TOF Mass Spectrometry Imaging (MSI) for Distribution Analysis of Anthocyanins in Strawberry Fruits. Application note (BRUKER)  2019年3月

報告書

榎元廣文*. 熟成肉の美味しさに関する研究ー代謝物の時空間的な解析ー. 浦上財団研究報告書 22 89-94 2015年3月

雑誌(和文)
榎元 廣文, 井上 菜穂子, 瀬藤 光利, 財満 信宏*. 農作物中の代謝物の質量顕微鏡法による解析. 食品加工技術 30(4) 153-159 2010年12月

青木孝良*, 榎元廣文, 林葉子. リン酸化による食品タンパク質の機能特性の改善. フードリサーチ 12 45-49 2009年12月 


李ソウ鵬, 林葉子, 榎元廣文, 八田一, 青木孝良*. リン酸塩存在下での乾燥加熱による食品タンパク質のリン酸化・多機能化. New Food Industry 48(3) 29-36 2006年3月